Manganese Amino Acid Chelate vs. Manganese Sulfate
Among 4,675 on-market manganese products with an identifiable primary form, 28% use Manganese Amino Acid Chelate (1,309 products) and 27.9% use Manganese Sulfate (1,306).
| Manganese Amino Acid Chelate | Manganese Sulfate | |
|---|---|---|
| Quality tier | Unrated | Tier 2 |
| Manganese by weight | 27.0% | 32.5% |
| Share of market | 28% | 27.9% |
| On-market products | 1,309 | 1,306 |
| Median declared dose | 2,000 elemental mcg middle half: 1,000–4,800 | 2,000 elemental mcg middle half: 2,000–2,500 |
| Most common brands | NOW, XYMOGEN, Bluebonnet | GNC Mega Men, GNC Women's Ultra Mega, 21st Century |
Doses are declared per serving in elemental mcg. “By weight” is the share of the ingredient that is the nutrient itself (e.g. elemental magnesium in a magnesium salt).
Why Manganese Amino Acid Chelate is unrated
Some animal (poultry) data are said to suggest higher relative bioavailability than MnSO4 (not cited here), but NIH ODS confirms no human data exist -- not willing to assert a human-relevant tier on animal-only evidence.
Source: https://ods.od.nih.gov/factsheets/Manganese-HealthProfessional/ (no human data); the animal/poultry evidence is not cited
Why Manganese Sulfate is tier 2
NIH ODS states no human comparative bioavailability data exist across manganese forms; treated as "acceptable by convention" (soluble reference salt used in mostly-animal research), not evidence-ranked.
Source: https://ods.od.nih.gov/factsheets/Manganese-HealthProfessional/