Quatrefolic (glucosamine salt of L-5-MTHF, brand)

Quatrefolic (glucosamine salt of L-5-MTHF, brand) is a tier 1 form of Folate (Vitamin B9), used in 198 on-market products and providing 56.2% elemental folate (vitamin b9) by weight.

Basis: free-acid L-5-MTHF MW 459.46 / Quatrefolic MW 817.81, a diglucosamine salt (confirmed PubChem formula)

Why this tier: Same active folate species as Metafolin/L-5-MTHF, using glucosamine instead of calcium as the salt-forming counterion for solubility. No head-to-head trial of Quatrefolic vs Metafolin vs generic L-5-MTHF was found -- treat any distinction between these three brands as uncertain.

Source: uncertain -- needs review for a brand-specific comparison

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