Extended/prolonged-release melatonin
Extended/prolonged-release melatonin is a tier 1 form of Melatonin, used in 0 on-market products .
0
on-market products
tier 1
quality tier
n/a
elemental fraction
Why this tier: Not "better/worse" than immediate-release in an absolute sense -- a different PK profile (longer half-life and sustained plasma levels), with RCT evidence for prolonged-release melatonin 2 mg in insomnia patients aged 55-80.
Source: Wade AG et al. 2007, Curr Med Res Opin 23(10):2597-605, PMID 17875243 (RCT, PR-melatonin 2 mg, age 55-80); Thanawala S et al. 2024, Pharmaceutics 16(10):1248, PMID 39458580 (SR vs IR PK: t1/2 5.1 vs 1.0 h)
Brands using this form
No on-market brand data available.